Discovery of small molecule bioactive agents from endophytic fungi of the Sonoran Desert

Authors

  • B.P. Bashyal
  • A.M. Burns
  • M.X. Liu
  • P.A. Paranagama
  • C.J. Seliga
  • T.J. Turbyville
  • E.M.K. Wijeratne
  • J. Zhan
  • M.K. Gunatilaka
  • A.E. Arnold
  • S.H. Faeth
  • L. Whitesell
  • A.A.L. Gunatilaka

DOI:

https://doi.org/10.33584/rps.13.2006.3061

Abstract

In our search for novel small molecule bioactive agents from endophytic fungi of the Sonoran desert, extracts derived from cultures of some selected endophytic fungal strains have been screened in assays for inhibition of heat shock protein 90 (Hsp90) activity, cancer cell proliferation and migration. Chaetomium chiversii, Chaetomium globosum, Fusarium acuminatum and Fusarium oxysporum producing metabolites active in these assays were cultured on large-scale and the derived extracts were subjected to bioactivity-guided fractionation to obtain a variety of natural products with diverse structures, and potential applications in cancer chemotherapeutics. This paper discusses the isolation, characterisation, and biological activity of some selected small molecule metabolites. Keywords: endophytic fungi, small molecule natural products, isolation, structure elucidation biological activity, cytotoxic agents, cell migration inhibitors; Hsp90 inhibitors

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Published

2007-01-01

How to Cite

Bashyal, B., Burns, A., Liu, M., Paranagama, P., Seliga, C., Turbyville, T., Wijeratne, E., Zhan, J., Gunatilaka, M., Arnold, A., Faeth, S., Whitesell, L., & Gunatilaka, A. (2007). Discovery of small molecule bioactive agents from endophytic fungi of the Sonoran Desert. NZGA: Research and Practice Series, 13, 211–214. https://doi.org/10.33584/rps.13.2006.3061

Issue

Vol. 13 (2007): 6th International Symposium on Fungal Endophytes of Grasses

Section

Past volumes

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